Acetyl tetrapeptide-5
is used in cosmetic eye formulations to decrease puffiness, eye bags, and dark circles by reducing edema and protecting proteins such as SOD from glycation
Alanine
Ala / A · hydrophobic residue · neutral charge
AOD-9604
is studied as an anti-obesity peptide that can reduce weight gain and increase fat oxidation in obese animal models with generally neutral effects on IGF-1 and glucose metabolism in early human trials
Arginine
Arg / R · basic residue · positive charge
Argireline
is a topical cosmetic peptide reported to decrease dynamic wrinkles by partially mimicking the mechanism of botulinum toxin in a non-invasive manner
Asparagine
Asn / N · polar residue · neutral charge
Aspartic acid
Asp / D · acidic residue · negative charge
BPC-157
is investigated for accelerating healing of gastrointestinal mucosa, tendons, ligaments, bone, and nervous tissue in preclinical models, with anti-inflammatory and pro-angiogenic effects
Comparison
While AOD-9604 is studied as an anti-obesity peptide that can reduce weight gain and increase fat oxidation in obese animal models with generally neutral effects on IGF-1 and glucose metabolism in early human trials71111115, Hexarelin is investigated for effects on GH secretion, cardiac protection, and muscle metabolism, with higher GH secretory potency than earlier GHRPs1929.
While AOD-9604 works as a synthetic fragment of human growth hormone corresponding to residues 176–191 with an added N-terminal tyrosine, retaining lipolytic but not growth-promoting actions; proposed to stimulate lipolysis and inhibit lipogenesis in adipose tissue, partly via β3-adrenergic pathways without significantly activating the full GH receptor–IGF-1 axis6171111, Hexarelin is a potent synthetic hexapeptide (examorelin) that agonizes GHSR-1a to stimulate GH release and also binds CD36, influencing cardiovascular and metabolic pathways19212996.
AOD-9604
Hexarelin
AOD-9604
GH1
Hexarelin
GHSR
Both peptides fall into a similar broad context as Hormone peptides, although the details of how they are used and discussed still diverge. Both are often discussed in Metabolic and endocrine contexts, while AOD-9604 is more of a metabolic peptide and Hexarelin is better described as a hormone peptide. Their biological logic is quite different: AOD-9604 is a hormone analog, whereas Hexarelin is a receptor agonist. AOD-9604 has a more synthetic analog origin, while Hexarelin is closer to synthetic design background and both are still best understood as being in Preclinical development. Hexarelin incorporates d-amino acid substitution and amidation features that are not part of AOD-9604, while their sequence patterns also diverge, with AOD-9604 showing hydrophobic domain features and Hexarelin showing protein-mimetic sequence features.
No related articles are linked to these peptides yet.