Comparison

Acetyl tetrapeptide-5 vs Hexarelin

Function

While Acetyl tetrapeptide-5 is used in cosmetic eye formulations to decrease puffiness, eye bags, and dark circles by reducing edema and protecting proteins such as SOD from glycation51150159154, Hexarelin is investigated for effects on GH secretion, cardiac protection, and muscle metabolism, with higher GH secretory potency than earlier GHRPs1929.

Mechanism

While Acetyl tetrapeptide-5 works as a synthetic tetrapeptide, Ac-βAla-His-Ser-His (Eyeseryl), with reported ACE-1 inhibition and anti-glycation activity, proposed to improve microcirculation and reduce capillary permeability and fluid accumulation in periorbital tissues51150159157, Hexarelin is a potent synthetic hexapeptide (examorelin) that agonizes GHSR-1a to stimulate GH release and also binds CD36, influencing cardiovascular and metabolic pathways19212996.

Length and Sequence

Acetyl tetrapeptide-5 is 4 amino acids long, whereas Hexarelin is longer as it has a length of 6 amino acids. Acetyl tetrapeptide-5 is made up of a sequence of βAla, Histidine, Serine, Histidine. Hexarelin is made up of a sequence of Histidine, Tryptophan, Alanine, Tryptophan, Phenylalanine, Lysine.

Receptor

Acetyl tetrapeptide-5

Acts as an enzyme inhibitor (eg, ACE-1, glycation-related pathways) rather than via a specific membrane receptor51159

Hexarelin

Primary: GHSR-1a (ghrelin receptor); also binds the scavenger receptor CD36 in vascular and macrophage tissues192129

Organism or Origin

Acetyl tetrapeptide-5

Fully synthetic cosmetic peptide (Eyeseryl) 150157

Hexarelin

Fully synthetic growth hormone secretagogue29

Gene

Acetyl tetrapeptide-5

Not assigned in the current dataset.

Hexarelin

GHSR

Related articles

No related articles are linked to these peptides yet.

Sources

51[PDF] Acetyl tetrapeptide-5 - SkinMiles, https://skinmiles.com/wp-content/uploads/2017/12/Matriskin-Ingredients.pdf
150The important eye peptide of acetyl tetrapeptide-5 - ChemicalBook, https://www.chemicalbook.com/article/the-important-eye-peptide-of-acetyl-tetrapeptide-5.htm
153Acetyl Tetrapeptide-5 (Eyeseryl) | CAS 820959-17-9 Manufacturer ..., https://www.conscientia-industrial.com/peptides/acetyl-tetrapeptide-5-eyeseryl-cas-820959-17-9
154Bioactive peptides in cosmetic formulations: Review of ..., https://www.sciencedirect.com/science/article/pii/S0196978125001019
157Effects of Peptides in Cosmetics, https://aapep.bocsci.com/resources/cosmetic-peptides.html
159Acetyl tetrapeptide-5 | ACE-1 Inhibitor | MedChemExpress, https://www.medchemexpress.com/acetyl-tetrapeptide-5.html
19Identification of the growth hormone-releasing peptide binding site ..., https://pmc.ncbi.nlm.nih.gov/articles/PMC1133797/
21Hexarelin Peptide | Strength & Recovery - Paragon Sports Medicine, https://www.paragonsportsmedicine.com/peptides/hexarelin
29Examorelin - Wikipedia, https://en.wikipedia.org/wiki/Examorelin
96Growth Hormone Secretagogue Receptor - ScienceDirect.com, https://www.sciencedirect.com/topics/biochemistry-genetics-and-molecular-biology/growth-hormone-secretagogue-receptor